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On October 20, 1976, Dr Guy Chouinard was the first to conduct a clinical trial of xanax in panic disorder. The peak plasma concentration is achieved in 1-2 hours. 50 patients were given either the xanax or a placebo during an 8-week double-blind controlled study. Once bound, the benzodiazepine locks the GABAA receptor into a conformation where the neurotransmitter GABA has much higher affinity for the GABAA receptor, increasing the frequency of opening of the associated Chloride ion channel and hyperpolarising the membrane.
In order for GABAA receptors to be sensitive to the action of benzodiazepines they need to contain an ? and a ? subunit, where the benzodiazepine binds.
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